domuz gribi (swine influenza A)

Bu linkte domuz gribi ile ilgili en güncel bilgiler,3 mayıs tarihinde tekrar gözden geçirilecek

http://dynaweb.ebscohost.com/Detail.aspx?id=435302&sid=ceecfc8e-d53b-40f5-9540-2e1329e6443b@SRCSM1

biyokimyauzmanları grubuna üye olmak için mailini yaz

biyokimyauzmanlari grubuna kayıt ol

E-posta:

Bu grubu ziyaret et

iyi kaynak

http://web2.iadfw.net/uthman/lab_test.html

bir metodun tanısal değerinin belirlenmesi,roc eğrileri

http://www.clinchem.net/Dersler/LabIst/ROC.htm

merck manuel online

http://www.merck.com/mmpe/index.html

bos biyokimyası

http://clinchem.net/Lab/BOS.htm

temel biyokimya animasyonları

http://www.wiley.com/college/fob/anim/

türkçe idrar atlası

http://www.mustafaaltinisik.org.uk/idrar/turkce/index.htm

animasyonlar

http://www.northland.cc.mn.us/biology/Biology1111/animations/

http://www.stolaf.edu/people/giannini/flashanimat/

http://www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/animations/#

http://pennhealth.com/health_info/animationplayer/

medikal biyokimya sayfası index hızlı ulaşım

http://themedicalbiochemistrypage.org/tmbp-sitemap.html

The List of Online and Free Access Journals about Biochemistry

Acta Biochimica Polonica
RKOJ:
chemistry, biochemistry
http://www.actabp.pl/

African Journal of Biochemistry Research
RKOJ:
biology, physicochemistry
www.academicjournals.org/ajbr

American Journal of Biochemistry and Biotechnology
RKOJ:
Life sciences, biochemistry, evolutionary biotechnology, structural biology, molecular biology, cellular biology, molecular medicine, cancer research, virology, immunology
http://scipub.org/scipub/ajbb/

Asian Journal of Biochemistry
RKOJ:
biochemistry
http://www.academicjournals.net/2/c4p.php?id=2&theme
=2&jid=ajb

Biochemia Medica
RKOJ:
biomedicine, biochemistry, laboratory diagnostics
http://hrcak.srce.hr/index.php?show=casopis&
id_casopis=121

Biokemistri
RKOJ:
biochemistry
http://www.bioline.org.br/bk

Bioscience Biotechnology and Biochemistry
RKOJ:
bioscience, biochemistry, biotechnology
http://www.jstage.jst.go.jp/browse/bbb

BMB Reports (Biochemistry and Molecular Biology Reports)
RKOJ:
biochemistry, molecular biology
http://www.jbmb.or.kr/index.html

Bulgarian Journal of Plant physiology
RKOJ:
plant physiology, plant biochemistry, stress plant physiology, plant molecular biology, applied plant physiology
http://www.bio21.bas.bg/ipp/gapbfiles/content.html

Chem-Bio Informatics Journal
RKOJ:
bioinformatics, biochemistry
http://www.jstage.jst.go.jp/browse/cbij

European Cells and Materials
RKOJ:
biology, biochemistry
http://www.ecmjournal.org/

General and Applied Plant Physiology
RKOJ:
plant physiology, plant biochemistry, stress plant physiology, plant molecular biology, applied plant physiology
http://www.bio21.bas.bg/ipp/gapbfiles/content.html

Indian Journal of Clinical Biochemistry
RKOJ:
clinical biochemistry, health care, laboratory science
www.ijcb.co.in/index.htm

International Journal of Biological Sciences
RKOJ:
cell biology, developmental biology, structural biology, microbiology, molecular biology, genetics, biochemistry, biotechnology, biodiversity, ecology, marine biology, plant biology, bioinformatics
http://www.biolsci.org/index.htm

Internet Electronic Journal of Molecular Design
RKOJ:molecular design, chemistry, biochemistry, biology
www.biochempress.com/

Nuclear Receptor Signaling
RKOJ:
nuclear receptor, nuclear coregulators, cell biology, endocrinology
www.nursa.org/nrs.cfm

Nucleic Acids Research (NAR)
RKOJ:
molecular biology, nucleic acid metabolism, chemistry, computational biology, genomics, molecular biology, RNA, structural biology
http://nar.oupjournals.org/

Structure and Mechanism in Protein Science: Guide to Enzyme Catalysis and Protein Folding


Nutrition & Metabolism
RKOJ:
nutrition, exercise physiology, clinical investigation, biochemistry, molecular biology, metabolism
www.nutritionandmetabolism.com/home/

Türk Biyokimya Dergisi
RKOJ:
biochemistry,molecular biology, molecular genetics, biotechnology, bioinformatics, bioengineering
www.turkjbiochem.com/eng/index.html

Klinik Araştırmalar için Bakanlığa Başvuru Şekli

http://www.iegm.gov.tr/beseritibbiurun/klinikarastirmalari/duzenlemeler/kilavuz/Documents/Bakanlıga%20basvuru%20kılavuzu.pdf

helsinki deklerasyonu

http://web.firat.edu.tr/sbd/eski/tez/etik.doc,

http://www.iegm.gov.tr/beseritibbiurun/klinikarastirmalari/duzenlemeler/kilavuz/Documents/Helsinki_Bildirgesi_(2008).pdf

Güzel bir kitap

http://rapidshare.com/files/46368000/Biochemistry__Clinical_Biochemistry_Illustrated_Color_Text.rar

renkli biyokimya atlası

http://rapidshare.com/files/115030001/Color_Atlas_of_Biochemistry_2nd_Edition.pdf

Mahhewsbiyokimya burdan indirilebilir

http://rapidshare.com/files/3610585/Biochemistry-Mathews.rar

http://www.bio-rad.com/B2B/BioRad/product/br_category.jsp?BV_SessionID=@@@@1855363217.1233317879@@@@&BV_EngineID=ccciadegggdfjlgcfngcfkmdhkkdfll.0&divName=Life+Science+Research&categoryPath=Catalogs/Life%20Science%20Research&lang=English&country=HQ&catLevel=2&loggedIn=false&serviceLevel=Lit+Request&catOID=-9263&isPA=false&cat_index=yes

bir çok ingilizce slayt

http://www.sigmaaldrich.com/life-science/cell-biology/learning-center/pathway-slides-and.html

Bakteriyoloji atlası

http://www.microbiologyatlas.kvl.dk/

Şeker Yüklemesi yaptıracak kişilerin test öncesi uygulaması tavsiye edilen 3 günlük diyet

ÖRNEK MENÜ

SABAH: 1 su bardağı süt
1 adet yumurta veya;
1 kibrit kutusu kadar beyaz peynir
1 tatlı kaşığı reçel, bal, pekmez
1 tatlı kaşığı yağ veya 5 zeytin
50 gr. Ekmek
Saat : 10.00 1 porsiyon meyve

ÖĞLE: 2 köfte büyüklüğünde et
1 porsiyon sebze yemeği
1 porsiyon tahıl yemeği (pilav, makarna, çorba, börek, vb.)
…Salata
1 porsiyon meyve
50 gr. Ekmek
Saat : 16.00 1 porsiyon meyve

AKŞAM: Öğle yemeği gibi

Kan alımında tavsiye edilen tüp sırası: (CLSI H3-A5 Standartlarına göre)

Kan alımında tavsiye edilen tüp sırası: (CLSI H3-A5 Standartlarına göre)

1● Kan kültürü
2● Koagulasyon
3● Jelli/Jelsiz Serum
4● Jelli/Jelsiz Heparin
5●EDTA
6● Diğerleri

faydalı

http://www.chemistryonline.com/news/16/clinicalbiochemistry.html

http://www.chemistryonline.com/news/13/medicalbiochemistry.html

Newborn Screening Tests

Organic acid metabolism disorders:
* IVA (isovaleric acidemia)
* GA I (glutaric acidemia)
* HMG (3-OH 3-CH3 glutaric aciduria)
* MCD (multiple carboxylase deficiency)
* MUT (methylmalonic acidemia due to mutase deficiency)
* Cbl A,B (methylmalonic acidemia)
* 3MCC (3-methylcrotonyl-CoA carboxylase deficiency)
* PROP (propionic acidemia)
* BKT (beta-ketothiolase deficiency)
Fatty acid oxidation disorders
* MCAD (medium-chain acyl-CoA dehydrogenase deficiency)
* VLCAD (very long-chain acyl-CoA dehydrogenase deficiency)
* LCHAD (long-chain L-3-OH acyl-CoA dehydrogenase deficiency)
* TFP (trifunctional protein deficiency)
* CUD (carnitine uptake defect)
Amino acid metabolism disorders:
* PKU (phenylketonuria)
* MSUD (maple syrup urine disease)
* HCY (homocystinuria due to CBS deficiency)
* CIT (citrullinemia)
* ASA (argininosuccinic acidemia)
* TYR I (tyrosinemia type I)
Hemoglobinopathies:
* Hb SS (sickle cell anemia)
* Hb S/Th (hemoglobin S/beta-thalassemia)
* Hb S/C (hemoglobin S/C disease)
Others:
* CH (congenital hypothyroidism)
* BIOT (biotinidase deficiency)
* CAH (congenital adrenal hyperplasia due to 21-hydroxylase deficiency)
* GALT (classical galactosemia)
* HEAR (hearing loss)
* CF (cystic fibrosis)

faydalı siteler

Online biyokimya(güzel site)
http://employees.csbsju.edu/hjakubowski/classes/ch331/bcintro/default.html


Medikal ingilizce eğitim
http://www.englishmed.com/

TÜM LABORATUVAR CİHAZLARI ile ilgili aradığınız bilgiler, teknik şartnameleri vs
http://www.labworld-online.com/index.html

"Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)"nin ENZİMLERE ilişkin kapsamlı bir sitesi
http://www.chem.qmw.ac.uk/iubmb/enzyme

International Federation Of Clinical Chemistry and Laboratory Medicine (IFCC)'nın Web Sitesi
http://www.ifcc.org/

OLDUKÇA YARARLI bir site
http://www.lib.washington.edu/Subject/Biochemistry/

"Online" olarak ulaşabileceğiniz BİYOKİMYA KİTABI ve DERGİLERİ
http://www.sc.edu/library/science/elbch.html

Summary of rejection characteristics

Error Condition High Pfr High Ped

No errors 12s

Random error 12.5s, 13s, 13.5s
R4s, R0.05, R0.01

Systematic error 22s, 41s, 2of32s, 31s
6x, 8x, 9x, 10x, 12x
x0.05, x0.01
cusum

koagülasyon kaskadı

Diabet

Secondary, or other specific types of diabetes mellitus are the result of many causes including:

1. Maturity onset type diabetes of the young (MODY) was previously considered to be a third form of type 2 diabetes. However, with the discovery of specific mutations leading to MODY, it is now classified under secondary or other specific types of diabetes. MODY is characterized by onset prior to age 25. All cases to date have shown impaired β-cell function. Patients may also exhibit insulin resistance and late β-cell failure. Evidence indicates that mutations in 10-12 different genes have been correlated with the development of MODY. Mutations in the 6 genes described here are all clearly correlated to MODY:

MODY1: the transcription factor identified as hepatic nuclear factor-4α (HNF-4α). This gene is also called transcription factor-14 (TCF14). Expression of HNF-4α is associated with the growth and normal functioning of the pancreas. Genes known to be regulated by HNF-4α include the insulin gene, glucose-6-phosphatase, GLUT2, the liver pyruvate kinase isoform (L-PK) which is also expressed in the pancreas, glyceraldehyde-3-phosphate dehydrogenase (G3PDH), aldolase B and thermogenin (uncoupling protein, UCP).

MODY2: pancreatic glucokinase

MODY3: the transcription factor HNF-1α. This gene is also called hepatocyte transcription factor-1 (TCF1). HNF-1α is known to regulate expression of the HNF-4α gene and also the GLUT2 and L-PK genes.

MODY4: the homeodomain transcription factor insulin promoter factor-1 (IPF-1). This gene is more commonly called PDX1 derived from pancreas duodenum homeobox-1.

MODY5: the transcription factor HNF-1β. This gene is also called hepatocyte transcription factor-2 (TCF2). HNF-1β is a critical regulator of a transcriptional network that controls the specification, growth, and differentiation of the embryonic pancreas. In humans, mutations in the HNF-1β gene are associated with pancreatic hypoplasia, defective kidney development and genital malformations.

MODY6: the bHLH transcription factor NeuroD1. NeuroD1 was first identified as a neural fate-inducing gene. The hamster β2 gene, shown to regulate insulin transcription is identical to NeuroD1 so the gene is often called NeuroD/β2.

2. Pancreatic disease: Pancreatectomy leads to the clearest example of secondary diabetes. Cystic fibrosis and pancreatitis can also lead to destruction of the pancreas.

3. Endocrine disease: Some tumors can produce counter-regulatory hormones that oppose the action of insulin or inhibit insulin secretion. These counter-regulatory hormones are glucagon, epinephrine, growth hormone and cortisol.

a. Glucagonomas are pancreatic cancers that secrete glucagon.

b. Pheochromocytomas secrete epinephrine.

c. Cushing syndrome results in excess cortisol secretion.

d. Acromegaly results in excess growth hormone production.

4. Drug-induced diabetes; treatment with glucocorticoids and diuretics can interfere with insulin function.

5. Anti-insulin receptor autoantibodies (Type B insulin resistance).

6. Mutations in the insulin gene.

7. Mutations in insulin receptor gene which lead to the syndromes listed below. Two clinical features are common in all syndromes that result from mutations in the insulin receptor gene: acanthosis nigricans and hyperandrogenism (the latter being observed only in females).

a. Donohue syndrome (also referred to as Leprachaunism)

b. Rabson-Mendenhall syndrome

c. Type A insulin resistance

8. Gestational diabetes; this syndrome sets in during pregnancy and usually resolves itself following childbirth.

9. Many other genetic syndromes have either diabetes or impaired glucose tolerance associated with them; lipoatrophic diabetes, Wolfram syndrome, Down syndrome, Klinefelter syndrome (XXY males), Turner syndrome, myotonic dystrophy, muscular dystrophy, Huntington disease, Friedreich ataxia, Prader-Willi syndrome, Werner syndrome, Cockayne syndrome, and others such as those indicated above

Diabetik ketoasidoz ve tedavi

Treatment of Diabetic Ketoacidosis

The following is not intended to be considered as routine orders for the diagnosis and treatment of all cases of DKA but is presented only as one possible treatment regimen. Each case of DKA must be treated on an individual basis.

Initial Assessment of DKA

blood glucose > 250mg/dL

arterial pH <7.3

serum bicarbonate <15mEq/L

urinary ketones ≥ 3+ and/or serum ketones are positive

Monitoring

vital signs every hour

serum glucose every hour and as needed

blood gas pH every 2 hrs (use arterial for 1st measurement then can use venous)

electrolytes every 1-2 hrs

urine ketones on each void

fluid input and output continuously

magnesium and phopshorous immediately and then every 1-2 hrs

Fluid Management

start normal saline at 1L/hr or 15-20ml/kg/hr initially

determine hydration status, goal being to replace 50% of estimated volume loss in the 1st 4hrs then remainder over next 8-12 hrs

infuse normal saline 125-500 ml/hr, rate dependent on hydration status

once serum Na+ is corrected infuse 1/2 normal saline at 4-14ml/kg/hr

when serum glucose reaches 250mg/dL change fluid to D5W 1/2 normal saline at same rate

Insulin Managementdiscontinue all oral diabetic medications and

previous insulin orders

give regular insulin iv bolus of 10 units

start insulin infusion usually at a rate of 0.15units/kg

insulin administration goal is to reduce serum glucose 50-70mg/dL/hr

when serum glucose is ≤ 150mg/dL then can switch to adult sq insulin with basal insulin

Potassium Management

if serum K+ is <3.3 give 40mEq/hr until it is >3.3

if serum K+ is >3.3 but <5.0 give 20-30mEq/L of iv fluids to keep serum K+ between 4-5mEq/L

if serum K+ is ≥5.0 do not give K+ but check serum levels every 2hrs

when replacing K+ both potassium chloride and potassium phosphate can be used

hold K+ replacement if patient urine output is <30ml/hr

Bicarbonate Management

assess need for bicarbonate by arterial pH measurement

if pH <6.9 give 100mEq sodium bicarbonate in 1L D5W and infuse at 200ml/hr

if pH is 6.9 - 7.0 give 50mEq sodium bicarbonate in 1L D5W and infuse at 200ml/hr

if pH >7.0 do not give bicarbonate

continue sodium bicarbonate administration until pH is >7.0

monitor serum K+

http://www.educypedia.be/education/chemistrybio.htm

http://library.med.utah.edu/NetBiochem/graphlis.htm

http://library.med.utah.edu/NetBiochem/titles.htm

http://themedicalbiochemistrypage.org/